Multiple urinary calculi caused by primary hyperoxaluria

Hyperoxaluria and renal calculi.

Many Western countries are experiencing an epidemic of renal calculi, causing immediate problems with acute pain and morbidity together with worries for the future because of the likelihood of recurrent stone formation. Renal or ureteric colic is the commonest surgical admission diagnosis in this country and it has been suggested that up to 12 million Americans will suffer a stone episode durin...

Primary Hyperoxaluria

Primary hyperoxalurias are rare recessive inherited inborn errors of glyoxylate metabolism. They are responsible for progressive renal involvement, which further lead to systemic oxalate deposition, which can even occur in infants. Primary hyperoxaluria type 1 is the most common form in Europe and is due to alanine-glyoxylate aminostransferase deficiency, a hepatic peroxisomal pyridoxin-depende...

Primary hyperoxaluria

Urinary calculi.

IJANTITATIVE CHEMICAL ANALYSES of urinary calculi have been done in these laboratories for some twenty years. During this time almost two thousand stones have been examined. In the early days of this period, the only quantitative method available was that of a complete analysis of the inorganic ions and organic compounds present, which was quite difficult and tedious. After the development of t...

Treatment of primary hyperoxaluria.

progress are discussed in relation to the known natural history of the disease. 6 of them probably have the usual form of primary hyperoxaluria associated with increased glycollic acid excretion, while 3 who are sibs have the recently described variant associated with L-glyceric aciduria and normal glycollic acid excretion. All 9 patients have been on regimens designed to increase the urinary s...